中国肺癌杂志Issue(10)：741-749,9.DOI:10.3779/j.issn.1009-3419.2014.10.06
MicroRNA调控肿瘤耐药的研究进展
Advances in Tumor Chemo-resistance Regulated by MicroRNA
摘要
Abstract
Chemotherapy is one of the primary treatment for malignant tumors. Tumor multidrug resistance (MDR) is a major cause of clinical failure of chemotherapy;however the mechanisms of chemo-resistance have not been fully elucidated. Recently, microRNA is one of the new hotspots in life science. MicroRNA regulates the expression of genes and plays roles a series of life events by post-transcriptional regulations, including cell proliferation, apoptosis, fat metabolism, ner-vous development, hormone secretion, tumor vessels generation, stem cell differentiation, tumor cell invasion and metastasis, and other physiological and pathological processes. Recent studies show that microRNA regulates the expression of multiple genes with high efficiency and specificity. The abnormal regulation of target genes by microRNA is responsible for tumor chemo-resistance, this may be an important component of the complexity of the regulation of chemo-resistance. hTerefore, the study of microRNA and tumor drug resistance has profound practical signiifcance. In this review, recent studies of tumor drug resistance, regulation of tumor drug resistance by microRNA, and microRNA as a potential target for tumor drug resistance therapy are reviewed.关键词
MicroRNA/肿瘤耐药/MDR/靶点Key words
MicroRNA/Chemo-resistance/MDR/Targets引用本文复制引用
林高阳(综述),徐克(审校)..MicroRNA调控肿瘤耐药的研究进展[J].中国肺癌杂志,2014,(10):741-749,9.基金项目
本研究受国家自然科学基金（No.81372519, No.30873035）、教育部留学回国人员科研启动基金、教育部博士点基金（No.20131202110005）、天津市应用基础及前沿技术研究计划重点项目（No.14JCZDJC33800, No.10JCZDJC20800）、天津市高等学校科技发展基金计划重点项目（No.ZD200714）资助This study was supported by the grants from the National Natural Science Foundation of China (No.81372519, No.30873035), the Scientiifc Research Foundation for the Returned Oversea Chinese Scholars from State Education Ministry of China, the Specialized Research Fund for the Doctoral Program of Higher Education of China (No.20131202110005), the Key Project of Tianjin Municipal Science and Technology Commission (No.14JCZDJC33800, No.10JCZDJC20800), and the Key Project of Tianjin Municipal Education Commission (All to Ke XU)(No.ZD200714) （No.81372519, No.30873035）
