中国肺癌杂志Issue(11)：812-818,7.DOI:10.3779/j.issn.1009-3419.2014.11.07
肿瘤细胞代谢与肿瘤转移相互关系的研究进展
Advances in the Relationship Between Tumor Cell Metabolism and Tumor Metastasis
摘要
Abstract
Intracellular nutrients and the rate of energy lfowing in tumor cells are otfen higher than that in normal cells due to the prolonged stress of tumor-speciifc microenvironment. In this context, the metabolism of tumor cells provides the fuel of bio-synthesis and energy required for tumor metastasis. Consistent with this, the abnormal metabolism such as extremely active glucose metabolism and excessive accumulating of fatty acid is also discovered in metastatic tumors. Previous Studies have conifrmed that the regulation of tumor metabolism can affect the tumor metastasis, and some of these have been successfully applied in clinical effective, positive way. hTus, targeting metabolism of tumor cells might be an effectively positive way to prevent the metastasis of tumor. So, our review is focused on the research development of the relationship between tu-mor metabolism and metastasis as well as the underlying mechanism.关键词
肿瘤/肿瘤细胞代谢/肿瘤转移Key words
Tumor/Metabolism of tumor cells/Tumor metastasis引用本文复制引用
张亚龙,房念珍,尤嘉琮,周清华..肿瘤细胞代谢与肿瘤转移相互关系的研究进展[J].中国肺癌杂志,2014,(11):812-818,7.基金项目
本文受国家863计划项目（No.2012AA02A201）、国家863计划项目（No.2012AA02A502）及国家自然科学基金（No.81000950）资助@@@@This review was supported by the grants from National 863 Plan Project (to Qinghua ZHOU)(No.2012AA02A201 and No.2012AA02A502) and National Science Foundation of China (to Jiacong YOU)(No.81000950) （to Qinghua ZHOU）
