中国肺癌杂志Issue(12)：834-838,5.DOI:10.3779/j.issn.1009-3419.2014.12.02
EGFR-TKI对肺癌新生淋巴管的影响及其意义
Effect of EGFR-TKI on Lymphangiogenesis of Lung Cancer withEGFR Mutation
摘要
Abstract
Background and objective hTis study aims to explore the effect of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKIs) on the lymphangiogenesis of lung cancer withEGFR mutation, as well as to determine the function of EGFR targeted therapy in relation to the inhibition of lymphangiogenesis during lung cancer treatment.Methods hTeEGFR double mutant lung cancer cell line NCI-H1975 is used to construct lung cancer xenogratf models. hTe models are divided into two groups:the solvent control group and the EGFR-TKI treatment group. Each group includes ifve mice. hTe inhibitory effect of EGFR-TKI on the growth of transplanted tumors was observed. Immunohistochemical method and lymphatic endothelium speciifc antibody D2-40 were used in the experiment to observe the inlfuence of EGFR-TKI on lymphangiogenesis in lung cancer.Results hTe weight and relative volume of tumors in the EGFR-TKI treated group were less than those in the solvent control group. hTe average lymphatic ves-sel density of EGFR-TKI-treated mice was 6.44 per case. hTis value was 10.70 per case in the solvent control group. Lower density of lymphangiogenesis was found in the EGFR-TKI treated group (P=0.023). hTe area and longest diameter of neonatal lymphatic vessel of the EGFR-TKI treated group were less than those of the solvent control group. Moreover, EGFR-TKI exhibited no signiifcant effect on the invasion of tumor cells into the lymphatic vessel (P=0.519).Conclusion EGFR-TKI can inhibit lymphangiogenesis inEGFR mutant lung cancer while suppressing vessel diameter and expansion area.关键词
肺肿瘤/EGFR突变/EGFR-TKI/新生淋巴管Key words
Lung neoplasms/EGFR mutation/EGFR-TKI/Lymphangiogenesis引用本文复制引用
蔡明辉,杨新颖,姜宝红,滕福康,潘雁,毛锋,申屠阳..EGFR-TKI对肺癌新生淋巴管的影响及其意义[J].中国肺癌杂志,2014,(12):834-838,5.基金项目
本研究受2013吴阶平医学基金会临床科研专项基金（No.320.6750.12218）资助hTis study was supported by the grant from Wu Jieping Medical Foundation (to Yang SHEN-TU)(No.320.6750.12218) （to Yang SHEN-TU）
