中国肺癌杂志Issue(3)：179-183,5.DOI:10.3779/j.issn.1009-3419.2015.03.09
Warburg效应及其对肿瘤转移的影响
Mechanism of Warburg Effect and Its Effect on Tumor Metastasis
摘要
Abstract
Cancer cells exhibit altered glucose metabolism characterized by a preference for aerobic glycolysis even when the oxygen content is normal, a phenomenon termed “Warburg eect”. However the definite molecular mechanisms of Warburg eect remains unclear, recent works indicated that it might be related to the abnormal activity of the oncogene and tumor suppressor genes, also the change of tumor microenvironment, the abnormal expression of glucose metabolic enzyme and so on. Warburg eect has a relationship with tumor progression and provide suitable conditions for tumor metastasis. is review will summarizes the mechanism of Warburg eect and its eect on tumor metastasis.关键词
Warburg效应/机制/肿瘤转移Key words
Warburg eect/Mechanism/Tumor metastasis引用本文复制引用
魏慧君,郭丽丽,李林(综述),周清华,吴志浩(审校)..Warburg效应及其对肿瘤转移的影响[J].中国肺癌杂志,2015,(3):179-183,5.基金项目
本研究受国家自然科学基金（No.81272359）、国家自然科学基金（No.30872936）及天津医科大学科研基金（No.0941501）资助is study was supported by the grants from National Science Foundation of China (both to Zhihao WU)(No.81272359)(No.30872936) （both to Zhihao WU）
and Science Foundation of Tianjin Medical University (to Lili GUO)(No.0941501) （to Lili GUO）
