中国感染控制杂志Issue(3)：170-173,4.DOI:10.3969/j.issn.1671-9638.2015.03.005
235株血流感染大肠埃希菌耐药性分析
Antimicrobial resistance of 235 strains of Escherichia coli isolated from patients with bloodstream infection
摘要
Abstract
Objective To investigate antimicrobial resistance of Escherichia coli (E.coli )isolated from patients with bloodstream infection,and provide evidence for rational use of antimicrobial agents in clinical practice.Methods BacT/A-lert automated blood culture system and VITEK 2 automated identification system were used for bacterial culture and identi-fication.Antimicrobial susceptibility testing and detection of extended-spectrum β-lactamases (ESBLs)-producing strains were performed by Kirby-Bauer method.Results From 2009 to 2011 ,a total of 235 strains of E.coli were isolated from patients with bloodstream infection,90 (38.30%)of which were ESBLs positive strains.The resistant rates of ESBLs-producing strains to ampicillin,cefotaxime and ceftriaxone were all 100%,but susceptibility rate to imi-penem/cilastatin and meropenem were all 100%,to cefmetazole and amikacin were >90%.The resistant rate of non-ESBLs-producing strains to ampicillin was the highest (70.63%),susceptibility rate to imipenem/cilastatin and meropenem were both 100%,to amikacin,cefotaxime,and cefmetazole were all >95%.The resistant rate of ES-BLs-producing strains was significantly higher than that of the non-ESBLs-producing strains.Ofβ-lactamase inhibi-tor,only susceptibility rate of ESBLs-producing E.coli to cefoperazone/sulbactam was>90%,susceptibility rates to piperacillin/tazobactam and ticarcillin/clavulanate were both<80%.Conclusion Antimicrobial resistant rate of ESBLs-producing strains causing bloodstream infection is high,individualized treatment strategies should be made according to antimicrobial resistance of bacteria causing infection in patients.关键词
血流感染/大肠埃希菌/耐药性/抗药性,微生物/抗菌药物/抗感染治疗/医院感染/合理用药Key words
bloodstream infection/Escherichia coli/drug resistance,microbial/antimicrobial agent/anti-infec-tive treatment/healthcare-associated infection/rational drug use分类
医药卫生引用本文复制引用
何卫平,崔恩博,王钱,鲍春梅,张文瑾,范振平,曲芬..235株血流感染大肠埃希菌耐药性分析[J].中国感染控制杂志,2015,(3):170-173,4.基金项目
全军医学科技“十二五”科研项目重点课题 （）
