中国感染控制杂志Issue(4)：223-226,4.DOI:10.3969/j.issn.1671-9638.2015.04.002
硝酸镓对临床分离金黄色葡萄球菌生物膜的体外清除作用
In vitro clearance effects of gallium nitrate on biofilms of clinically isola-ted Staphylococcus aureus
摘要
Abstract
Objective To study the effect of new type antiseptic gallium nitrate on the clearance of Staphylococcus aureus (S .aureus)biofilm,and explore new methods for suppressing bacterial biofilm formation.Methods Biofilm positive strains were screened among 14 clinically isolated S .aureus strains by crystal violet staining method,mini-mal inhibitory concentration (MIC)of gallium nitrate for biofilm positive strains and effect of gallium nitrate on the clearance of biofilm were measured.Results Of 14 S .aureus isolates,9 were biofilm positive strains;gallium ni-trate MICs for S .aureus ATCC 25923,biofilm-negative strain,and 9 biofilm positive strains were all 16 μg/mL;the clearance rate of gallium nitrate for early biofilm of S .aureus was significantly higher than mature biofilm ([86.53±0.96]% vs [62.54±1 .53]%,t=35.699,P <0.001 ).Conclusion Gallium nitrate can inhibit growth of S .aureus strains and clear biofilm,it can be applied in the prevention and control of S .aureus infection.关键词
金黄色葡萄球菌/生物膜/硝酸镓/清除Key words
Staphylococcus aureus/biofilm/gallium nitrate/clearance分类
医药卫生引用本文复制引用
吴浩昕,李蓉,葛新..硝酸镓对临床分离金黄色葡萄球菌生物膜的体外清除作用[J].中国感染控制杂志,2015,(4):223-226,4.基金项目
武警后勤学院科研基金面上项目 （）
