中国感染控制杂志Issue(5)：325-328,4.DOI:10.3969/j.issn.1671-9638.2015.05.010
急性白血病患儿医院感染病原菌及危险因素分析
Pathogens and risk factors of healthcare-associated infection in children with acute leukemia
摘要
Abstract
Objective To explore the main sites,pathogen distribution and risk factors of healthcare-associated in-fections (HAI)in children with acute leukemia,and provide scientific evidence for prevention and treatment. Methods Data of 828 children with acute leukemia admitted to a hospital in 2011 -2012 were collected,infection site,pathogen distribution and risk factors of infection were analyzed.Results Of 828 patients,184 cases and 196 times of HAI occurred with the incidence of 22.22% and 23.67%,respectively.HAI occurred mostly in respiratory tract (52.56%).A total of 96 pathogenic strains were isolated,among which gram-negative and gram-positive bac-teria accounted for 58.33%(n=56)and 29.17%(n=28)respectively.Univariate analysis revealed that risk factors for HAI were leukemia remission induction chemotherapy,hospital stay ≥ 30 days,peripheral leukocyte count (WBC)≤3×109/L,granulocyte count ≤0.5 ×109/L,and acute nonlymphocytic leukemia.Multivariate analysis revealed that hospital stay ≥30 days was independent risk factors for HAI.Conclusion Children with acute leuke-mia have a high incidence of HAI,infection mainly occurs in respiratory system,and gram-negative bacteria are ma-jor pathogens.The incidence of HAI is correlated with remission induction chemotherapy,long length of hospital stay,low WBC,low number of neutrophils,and acute myeloid leukemia.关键词
急性白血病/医院感染/危险因素/病原菌Key words
acute leukemia/healthcare-associated infection/risk factor/pathogen分类
医药卫生引用本文复制引用
丁蓉芳,孙树梅..急性白血病患儿医院感染病原菌及危险因素分析[J].中国感染控制杂志,2015,(5):325-328,4.基金项目
2010年度院长基金 （）
