局解手术学杂志Issue(3)：250-252,3.DOI:10.11659/jjssx.1672-5042.201403011
环孢素A对严重创伤失血性休克大鼠的治疗作用
Beneficial effects of Cyclosporin A on traumatic hemorrhagic shock in rats
摘要
Abstract
Objective To investigate the beneficial effects of cyclosporin A ( CsA) on traumatic hemorrhagic shock in rats. Methods The traumatic hemorrhagic shock model was adopted in 144 SD rats which were divided into 6 groups: sham-operated group,shock control group,lactated Ringer's solution ( LR) group,CsA 1 mg/kg,5 mg/kg and 10 mg/kg group. The effects of three doses of CsA on the animal survival time and 24 h survival rate were observed,and the effects of CsA on hemodynamic parameters,including mean arterial blood pressure ( MAP) ,left intraventricular systolic pressure ( LVSP) ,left ventricular end-diastolic pressure ( LVEDP) ,maximal change rate of left intraven-tricular pressure ( ± dp/dtmax ) and heart rate ( HR) were also observed. Results CsA at the concentration of 5 mg/kg and 10 mg/kg can significantly increase the survival time and 24 h survival rate of shock rats,the survival rate was increased to 56. 3% from 25% of LR group. After shock,the hemodynamic parameters were significantly decreased including MAP,LVSP and ± dp/dtmax ,LR infusion only improved the hemodynamics to some extent,which were significantly lower than those in sham-operated group. CsA (5 mg/kg and 10 mg/kg) can signifi-cantly improve the hemodynamics of shock rats including LVSP and ± dp/dtmax ,which were increased at 2 h after resuscitation as compared to LR group,and return to about normal levels. 1 mg/kg of CsA also restored the hemodynamic parameters, but there were no significant differences between CsA 1 mg/kg group and LR group. Conclusion CsA has good beneficial effect on traumatic hemorrhagic shock,and 5 mg/kg and 10 mg/kg of CsA showed a better effect.关键词
失血性休克/创伤/环孢素A/血流动力学Key words
hemorrhagic shock/trauma/cyclosporin A/hemodynamics分类
医药卫生引用本文复制引用
杨光明,彭小勇,李涛,徐竞,刘良明..环孢素A对严重创伤失血性休克大鼠的治疗作用[J].局解手术学杂志,2014,(3):250-252,3.基金项目
国家自然科学基金项目（81270400) （）
国家自然科学基金青年基金项目（30901559) （）
重庆市基础与前沿研究计划项目（cstc2013jcyjA10012) （）
国家重点实验室专项课题（SKLZZ201020) （）
