局解手术学杂志Issue(3)：260-262,263,4.DOI:10.11659/jjssx.03E015017
雷珠单抗联合光凝治疗糖尿病视网膜病变黄斑水肿
Bevacizumab intravitreal injection with photocoagulation for diabetic retinopathy macular edema
摘要
Abstract
Objective To observe the clinical efficacy of bevacizumab intravitreal injection combined with laser photocoagulation for di-abetic retinopathy macular edema(DME). Methods 25 DME patients (15 patients, 24 eyes in control group and 10 patients,13 eyes in treatment group) were selected from January 2013 to November 2014 in our hospital. The control group received single Krypton laser (510 nm red and 483 nm yellow) grid photocoagulation or big“C” photocoagulation, while the treatment group received bevacizumab intrav-itreal injection after Krypton laser photocoagulation. The visual acuity were checked, and the macular retinal thickness was detected by opti-cal coherence tomography ( OCT) . Results The difference in preoperative visual acuity between the two groups was not statistically signifi-cant (P>0. 05). All visual acuity improved significantly (P<0. 05) after treatment and the treatment group got a better result compared to the control group(P <0. 05). The preoperative macular retinal thickness in treatment and control groups were respectively (510. 75 ± 61. 06)μm and(487. 47 ± 43. 41)μm, and the difference between them was not statistically significant (P>0. 05). And the macular retinal thickness were respectively ( 253. 41 ± 39. 12 )μm and ( 358. 81 ± 43. 24 )μm after treatment, which were all decreased than before (P<0. 05). The macular retinal thickness of the treatment group was better than that of the treatment group after treatment (P<0. 05). Conclusion Single Krypton laser photocoagulation and bevacizumab intravitreal injection combined with Krypton laser photocoagulation are all effective for DME. But treatment combined with Krypton laser photocoagulation could get significantly better postoperative visual acuity re-covery and significantly faster absorption of macular edema.关键词
糖尿病视网膜病变/黄斑水肿/雷珠单抗/光凝Key words
diabetic retinopathy macular edema/macular oedema/bevacizumab/photocoagulation分类
医药卫生引用本文复制引用
刘凌,刘勇,阴正勤..雷珠单抗联合光凝治疗糖尿病视网膜病变黄斑水肿[J].局解手术学杂志,2015,(3):260-262,263,4.基金项目
国家自然科学基金(81470671) （81470671）
