局解手术学杂志Issue(3)：287-289,3.DOI:10.11659/jjssx.06E014318
胃癌HIF-1α表达及其与胃癌术后复发的相关性研究
HIF-1αexpression in gastric cancer and its correlation with gastric cancer recurrence
高树全 1仲婷婷 1催大鹏1
作者信息
- 1. 北方学院附属第一医院肝胆外科，河北 张家口075000
- 折叠
摘要
Abstract
Objective To study the expression of HIF-1αand and its correlation with gastric cancer recurrence, and to identify its prog-nosis evaluation in gastric cancer recurrence. Methods 80 patients with gastric cancer recurrence after radical surgery were selected as the observation group, and 50 patients without gastric cancer recurrence 5 or more than 5 years after surgery were selected as the control group. The immunohistochemical situation and expression of VEGF of the two groups were compared, and the correlation of HIF-1αand VEGF and gastric cancer recurrence were analyzed. Results The positive expression rate of HIF-1αand VEGF were 77. 50% and 73. 75% respectively in the observation group, which were significantly higher than 12. 00% and 10. 00% in the control group. Univariate analysis showed that the related indices such as degree of differentiation, depth of invasion, lymph node metastasis, vascular invasion, and TNM clinical stage were associated with VEGF expression and positive expression of HIF-1α. The Spearman correlation analysis showed that HIF-1α and VEGF was positively correlated (r=0. 458,P=0. 000). 1-year survival rate of HIF-1α-positive group was 45. 16%, and the average survival time was (8. 62 ± 2. 32) months, which was significantly lower than 77. 77% and (18. 96 ± 3. 14) months respectively in the negative group. Cox risk model analysis showed that HIF-1αand VEGF expression were high risk factors for gastric cancer recurrence. Conclusion HIF-1αand VEGF expression have a very colse correlation with gastric cancer recurrence, and it can be used as evaluation of gastric cancer recurrence and prognosis.关键词
胃癌复发/HIF-1α表达/VEGFKey words
gastric cancer recurrence/HIF-1α expression/VEGF分类
医药卫生引用本文复制引用
高树全,仲婷婷,催大鹏..胃癌HIF-1α表达及其与胃癌术后复发的相关性研究[J].局解手术学杂志,2015,(3):287-289,3.
