中国康复Issue(6)：433-435,3.DOI:10.3870/zgkf.2014.06.011
肉毒毒素注射结合功能训练对痉挛型脑瘫患儿站立与步行功能的影响
Effects of botulinum toxin A injection in combination with functional training on standing and walking in children with spastic cerebral palsy
摘要
Abstract
Objective:To study the effects of botulinum toxin A (BTX‐A) injection in combination with functional training on standing and walking in children with spastic cerebral palsy (SCP) .Methods:One hundred children with SCP were randomly divided into a BTX‐A group and a control group (n= 50 each) .The children in the BTX‐A group were treated with BTX‐A injected into spastic muscles in the lower extremity combined with functional train‐ing ,and those in the control group with functional training alone .Composite to Spasticity Scale (CSS) scores and Gross Motor Function Measure (GMFM) DE scores were recorded before and at 2nd week ,and 3rd month and 6th month after treatment .Results:After treatment for 2 weeks ,3 months and 6 months ,CSS scores in the lower ex‐tremity were significantly reduced as compared with those before treatment ,and those at 3rd and 6th month after treatment were significantly lower than in the control group (P<0 .05) .The GMFM (DE) scores after treatment were significantly increased in both two groups as compared with those before treatment ,and those at 3rd and 6th month after treatment were significantly higher than in the control group (P<0 .05) .Conclusion:BTX‐A injection or functional training can release spastic muscles in the lower extremity ,and improve their activity ability .BTX‐A injection in combination with functional training is more effective on reducing spasticity and improving functional standing and walking in children with SCP .关键词
A型肉毒毒素/下肢痉挛/脑瘫Key words
botulinum toxin A/lower extremity spasticity/cerebral palsy分类
医药卫生引用本文复制引用
谭红香,徐开寿,何璐,郑韵,麦坚凝,李金玲..肉毒毒素注射结合功能训练对痉挛型脑瘫患儿站立与步行功能的影响[J].中国康复,2014,(6):433-435,3.基金项目
广州市卫生局资助项目（20131A011067）； （）
