中国康复Issue(2)：88-89,2.DOI:10.3870/zgkf.2015.02.002
电针百会穴对小鼠大脑中动脉栓塞的保护作用研究
Protective effects of electroacupuncture on Baihui on permanent middle cerebral artery occlusion
摘要
Abstract
Objective:To study the protective effect of electroacupuncture (EA)on Baihui on mice model of perma-nent occlusion of middle cerebral artery (MCAO).Methods:The MCAO model of mice were established and subjec-ted to cerebral infarction by intraluminal occlusion of the middle cerebral artery.After intervention for 4 weeks,the lesion volume,the neurological impairment scores and the expression of Bcl-xl were observed and compared between the EA group and acupuncture group (psydoacupuncture).Patch clamp method was used in the the surrounding area of the infarction,and the change of BK-channel was observed.Result:The lesion volume and the neurological im-pairment scores in EA group were significantly reduced as compare with those in acupuncture group (P <0.01 ). The expression of Bcl-xl was higher in EA group than in acupuncture group (P <0.01).Patch clamp results showed that the BK-channel function of the neurons in EA group was significantly better than in acupuncture group in the surrounding area of the infarction (P <0.01).Conclusion:EA on Baihui can reduce the lesion volume and improve neurological function probably by up-regulating the expression of Bcl-xl and also by improving the function of neu-rons BK-channel.关键词
电针/小鼠/脑梗死/BK-channelKey words
electroacupuncture/mice/cerebral infarction/BK-channel分类
医药卫生引用本文复制引用
蔡璇,许菁,徐姣,潘邓记..电针百会穴对小鼠大脑中动脉栓塞的保护作用研究[J].中国康复,2015,(2):88-89,2.基金项目
国家自然基金(81371222) （81371222）
