中国康复理论与实践Issue(5)：451-454,4.DOI:10.3969/j.issn.1006-9771.2014.05.014
Duchenne型肌营养不良认知障碍机制研究进展
Mechanisms of Cognitive Impairment of Duchenne's Muscular Dystrophy (review)
付雅 1吴士文1
作者信息
- 1. 安徽医科大学武警总医院临床学院，北京市100039
- 折叠
摘要
Abstract
Duchenne's muscular dystrophy (DMD) is a common X-linked recessive neuromuscular disorder that associated with a spec-trum of genetically based cognitive and behavioral disabilities. Several mechanisms have been discussed as the cause of cognitive impair-ment in patients with DMD: absence of different dystrophin isoforms, impairments in neurogenesis, changes of synaptic plasticity, blood-brain barrier alterations, brain metabolic differences, cerebellum disfunction, etc.关键词
Duchenne型肌营养不良/认知障碍/抗肌萎缩蛋白/突触/血脑屏障/代谢/小脑/综述Key words
Duchenne's muscular dystrophy/cognitive impairment/dystrophin/synapse/blood-brain barrier/metabolism/cerebellum/review分类
医药卫生引用本文复制引用
付雅,吴士文..Duchenne型肌营养不良认知障碍机制研究进展[J].中国康复理论与实践,2014,(5):451-454,4.
