中国康复理论与实践Issue(8)：713-717,5.DOI:10.3969/j.issn.1006-9771.2014.08.003
原花青素对急性脊髓损伤大鼠核因子-кB和白细胞介素-6表达的影响
Effect of Proanthocyanidin on Expression of Nuclear Factor kappa B and Interleukin-6 in Rats after Spinal Cord Injury
摘要
Abstract
Objective To observe the effect of proanthocyanidin on the expression of nuclear factor kappa B (NF-кB) and interleukin-6 (IL-6) in rats with spinal cord injury (SCI). Methods 36 healthy adult Sprague-Dawley rats were randomly divided into proanthocyanidin treatment group (group A, n=12), methylprednisolone (MP) treatment group (group B, n=12) and model control group (group C, n=12). Al-len's method was used to establish the model of acute spinal cord injury in T9. On the 1st, 3rd and 7th days after operation, 4 rats in each group were assessed with Basso-Beattie-Bresnahan (BBB) scale and Slanting Board Test (SBT), and the expression of NF-кB and IL-6 of the spinal cord were detected with immunohistochemistry. Results The scores of BBB and SBT were better in groups A and B than in the group C 3 and 7 days after SCI (P<0.05). Compared with group C, the expression of NF-кB in group A decreased all the time after SCI (P<0.01), and 3 and 7 days after SCI in group B (P<0.01);while the expression of IL-6 decreased all the time after SCI in groups A and B (P<0.05). Conclusion Proanthocyanidin may inhibit the expression of NF-кB and IL-6 in spinal cord after SCI in order to reduce inflammation and improve the hindlimb motor function in rats after SCI.关键词
脊髓损伤/原花青素/运动功能/核因子-кB/白细胞介素-6/大鼠Key words
spinal cord injury/proanthocyanidin/motor function/nuclear factor kappa B/interleukin-6/rats分类
医药卫生引用本文复制引用
马延仃,张晓,谢少华,杨拯,杨海燕,李晓,张艺,梁羽,郭秀娟,张奇兰..原花青素对急性脊髓损伤大鼠核因子-кB和白细胞介素-6表达的影响[J].中国康复理论与实践,2014,(8):713-717,5.基金项目
1.2013年国家级大学生创新实验计划项目(No.201313705002)；2.成都医学院大学生创新实验计划项目(No.CXXS201307)。 （No.201313705002）
