中国康复理论与实践Issue(12)：1175-1178,4.DOI:10.3969/j.issn.1006-9771.2014.12.021
活动性关节结核全血γ-干扰素检测结果分析
Testing Result of Active Joint Tuberculosis's Whole Blood Interferon-γAssay
摘要
Abstract
Objective To discuss the significance of the detection of interferon-γin the diagnosis of active joint tuberculosis. Methods 5 kinds of specific proteins of mycobacterium tuberculosis were used as stimulating protein, the chemiluminescence enzyme immunoassay was used to test the content of interferon-γ. The interferon-γof 35 cases of patients with active joint tuberculosis and 35 cases of healthy people were detected. The difference of the sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ra-tio and negative likelihood ratio of 5 kinds of proteins to the diagnostic of active joint tuberculosis were compared. Results CFP10/ESAT6 fusion protein, Rv2041c protein, Rv0057/1352 fusion proteins, Rv1419 protein and Rv1656 protein were used as stimulating protein, the sensitivities of active joint tuberculosis by the whole blood interferon-γassay were 77.1%, 68.6%, 71.4%, 74.3%and 65.7%. The specifici-ties were 65.7%, 54.3%, 57.1%, 60.0%and 62.9%. The positive predictive values were 62.9%, 60%, 62.5%, 65%and 63.9%. The negative predictive values were 74.2%, 63.3%, 66.7%, 70%and 64.7%. The positive likelihood ratios were 2.25, 1.5, 1.67, 1.86 and 1.77. The nega-tive likelihood ratios were 0.348, 0.579, 0.5, 0.429 and 0.545. Conclusion The detection of interferon-γhas certain significance to joint tu-berculosis. But it is not as an index of diagnosing joint tuberculosis.关键词
关节结核/γ-干扰素/诊断/结核分枝杆菌/特异性蛋白Key words
joint tuberculosis/interferon-gamma/diagnosis/mycobacterium tuberculosis/specific proteins分类
医药卫生引用本文复制引用
朱森,黄迅悟,梁艳,彭伟,冯会成,张瑞斐..活动性关节结核全血γ-干扰素检测结果分析[J].中国康复理论与实践,2014,(12):1175-1178,4.基金项目
首都临床特色应用研究项目(No. Z1211070010112094)。 （No. Z1211070010112094）
