中国康复理论与实践Issue(1)：22-25,4.DOI:10.3969/j.issn.1006-9771.2015.01.006
运动预处理对脑缺血再灌注大鼠血清炎症因子水平的影响
Effects of Exercise Preconditioning on Inflammatory Response in Serum in Rat after Cerebral Ischemia-reperfusion
摘要
Abstract
Objective To investigate the effect of exercise preconditioning on serum level of tumor necrosis factorα(TNF-α), interleu-kin (IL)-1βand IL-6 in rats after cerebral ischemia-reperfusion (I/R). Methods 24 male Sprague-Dawley rats were randomly divided into exercise preconditioning group (n=8), model group (n=8) and sham group (n=8). The middle cerebral arteries were occluded for 120 min and re-perfused. All the rats were evaluated with neurological deficit score 2 hours, 24 hours after I/R. The serum levels of TNF-α, IL-1βand IL-6 was detected with enzyme-linked immunosorbent, and the pathology was observed with HE staining 24 hours after I/R. Results The neurological deficit score decreased in the exercise preconditioning group compared with that in the model group, as well as the serum TNF-α, IL-1βand IL-6 (P<0.05) 24 hours after I/R. The pathological damage and interstitial edema alleviated in cerebral ischemia cortical, and the degeneration and necrosis of the neurons in the ischemic area significantly reduced in the exercise preconditioning group. Conclu-sion Exercise preconditioning may inhibit inflammatory response in I/R rats to protect neurological function from impairment.关键词
脑缺血再灌注/运动预处理/肿瘤坏死因子α/白细胞介素-1β/白细胞介素-6/炎症反应Key words
cerebral ischemia-reperfusion/exercise preconditioning/tumor necrosis factorα/interleukin-1β/interleukin-6/inflamma-tory response分类
医药卫生引用本文复制引用
朱路文,叶涛,吴孝军,姜云飞,唐强..运动预处理对脑缺血再灌注大鼠血清炎症因子水平的影响[J].中国康复理论与实践,2015,(1):22-25,4.基金项目
1.哈尔滨市科技创新人才专项基金(青年后备人)(No.2014RFQGJ150)；2.黑龙江中医药大学领军人才计划项目(No.2012RCL02)；3.黑龙江省高校科技创新团队计划项目(No.2013TD007)。 （青年后备人）
