中国康复理论与实践Issue(1)：26-30,5.DOI:10.3969/j.issn.1006-9771.2015.01.007
不同强度运动对脑缺血再灌注大鼠学习能力及氧自由基代谢的影响
Effect of Intensity of Exercise on Learning Ability and Oxygen Free Radical Metabolism in Rats after Cerebral Ischemia-reperfu-sion
摘要
Abstract
Objective To explore the effetc of different intensity of exercise on learning ablility and oxygen free radical metabolism in rats after cerebral ischemia-reperfusion (I/R). Methods 60 male Sprague-Dawley rats were randomly divided into sham group, I/R group, aerobic exercise preconditioning group and exhaustive exercise preconditioning group. The morphological changes of neural cells in hippo-campus were observed with HE staining, the learning ablility was assessed with shuttle box, the activity of superoxide dismutase and malo-ndialdehyde level in hippocampus were measured with hydroxylamine method and TBA method respectively 1, 3, 7 days after injury. Re-sults The number of survival neurons, active avoidance reaction and activity of superoxide dismutase decreased, and the latency of passive avoidance and malondialdehyde levels increased in all the other groups compare with the sham group (P<0.001). Further more, the number of surviving neurons, active avoidance reaction rate and the activity of superoxide dismutase were less in the I/R group than in the aerobic exercise preconditioning group (P<0.001), and more than in the exhaustive exercise preconditioning group (P<0.001), while the latency of passive avoidance and the level of malondialdehyde was more than in the aerobic exercise preconditioning group (P<0.001), and less than in the exhaustive exercise preconditioning group (P<0.001). Conclusion Regular aerobic exercise is beneficial to protect the learning ability from cerebral I/R in rats, but exhaustive exercise may be negative, which may associated with the metabolism of oxygen free radical in hip-pocampus impacted by exercise.关键词
脑缺血再灌注/学习/有氧运动/力竭运动/氧自由基/大鼠Key words
cerebral ischemia-reperfusion/learning/aerobic exercise/exhaustive exercise/oxygen free radical/rats分类
医药卫生引用本文复制引用
孙竹梅,赵雅宁,李建民,陈长香,赵旭,陈乃玲..不同强度运动对脑缺血再灌注大鼠学习能力及氧自由基代谢的影响[J].中国康复理论与实践,2015,(1):26-30,5.基金项目
河北省教育厅重点资助项目(No.ZH2012046)。 （No.ZH2012046）
