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热射病大鼠的学习记忆功能研究

张进进 王恒 房效莉 周立冬 吴士文

中国康复理论与实践Issue(3):272-275,4.
中国康复理论与实践Issue(3):272-275,4.DOI:10.3969/j.issn.1006-9771.2015.03.007

热射病大鼠的学习记忆功能研究

Learning and Memory Function of Rats after Heat Stroke

张进进 1王恒 1房效莉 2周立冬 3吴士文1

作者信息

  • 1. 安徽医科大学武警总医院临床学院,北京市100039
  • 2. 徐州医学院,江苏徐州市221000
  • 3. 武警总医院医学实验中心,北京市100039
  • 折叠

摘要

Abstract

Objective To observe the learning and memory function of rats after heat stroke. Methods 60 Sprague-Dawley rats were di-vided randomly into heat stroke group (n=44), sham group (n=8) and control group (n=8). They were tested with the Morris Water Maze 7 days after modeling. The escaping latency was recorded in the first 5 days, and it was recorded with frequency crossing the platform area and the duration in the target quadrant after ridding the platform on the 6th day. Results 16 rats died in the heat stroke group after modeling. The escaping latency increased (P<0.05), and the cumulative duration in the target quadrant and the frequency of crossing the previous plat-form decreased (P<0.05) in the heat stroke group compared with the other groups. Conclusion The learning and memory ability is impaired after heat stroke in rats.

关键词

热射病/Morris水迷宫/学习记忆/认知功能/大鼠

Key words

heat stroke/Morris Water Maze/learning and memory/cognitive function/rats

分类

医药卫生

引用本文复制引用

张进进,王恒,房效莉,周立冬,吴士文..热射病大鼠的学习记忆功能研究[J].中国康复理论与实践,2015,(3):272-275,4.

基金项目

国家发改委卫星专项基金项目(No.发改办高技[2013]2140)。 (No.发改办高技[2013]2140)

中国康复理论与实践

OA北大核心CSCDCSTPCD

1006-9771

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