中国康复理论与实践Issue(4)：397-401,5.DOI:10.3969/j.issn.1006-9771.2015.04.007
银杏叶提取物对脊髓损伤后大鼠肠道功能的影响
Effect of Ginkgo Biloba Extract on Intestinal Function after Spinal Cord Injury in Rats
摘要
Abstract
Objective To observe the effect of Ginkgo biloba extract (EGb) on intestinal function after spinal cord injury (SCI) in rats. Methods 36 Sprague-Dawley rats were randomly divided into group A (n=12), group B (n=12) and group C (n=12). SCI model was estab-lished with Allen's mode (10 g × 25 mm) at T10. 30 minutes later, group A was intraperitoneally injected with methylprednisolone 30 mg/kg every 24 hours;group B was injected with Shuxuening injection (EGb) 1.75 mg/kg every 24 hours;group C were injected with equal vol-ume of saline. The slow wave of intestinal smooth muscle was measured, the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in serum were determined 1 day, 3 days and 7 days after modeling, while intestinal tissue was tested with HE stain-ing. Results The amplitude and frequency of the myoelectric slow wave increased in the groups A and B 3 and 7 days after modeling com-pared with those in the group C (P<0.05);meanwhile, the activity of SOD increased and content of MDA decreased in the groups A and B (P<0.05). The HE scores decreased in the groups A and B compared with those in the group C (P<0.05), which presented that the inflamma-tory exudation was mild, the hemorrhagic spot was few and the area was limited. The intestinal villous of the group C was blunt with large infiltration of inflammatory cells and inflammatory exudate on the mucosal surface. Conclusion EGb can improve the recovery of intestinal function in rats spinal cord injury through antioxidant.关键词
银杏叶提取物/脊髓损伤/丙二醛/超氧化物歧化酶/肠道功能障碍Key words
Ginkgo biloba extract/spinal cord injury/malondialdehyde/superoxide dismutase/gastrointestinal dysfunction分类
医药卫生引用本文复制引用
李欣芮,罗兰,杨拯,王强,宋强,陈勇,黄倩,聂欢,陈建敏..银杏叶提取物对脊髓损伤后大鼠肠道功能的影响[J].中国康复理论与实践,2015,(4):397-401,5.基金项目
1.成都医学院大学生创新实验计划项目(No. CXXS201307)；2.成都医学院实验室开放项目(No. Kf201401)。 （No. CXXS201307）
