中国康复理论与实践Issue(4)：460-463,4.DOI:10.3969/j.issn.1006-9771.2015.04.021
395例脊髓损伤患者医院感染的病原菌分布和耐药情况分析
Distribution and Drug-resistance of Pathogens of Nosocomial Infection in Spinal Cord Injury：395 Cases Re-port
赵国伟 1高钧1
作者信息
- 1. 中国康复研究中心北京博爱医院药剂科，北京市100068
- 折叠
摘要
Abstract
Objective To pave the way for clinical therapy and reasonable administration of antibiotics, and to analyze the kinds and drug-resistance of pathogens of nosocomial infection in patients with spinal cord injury. Methods Bacteriology of infection and drug resis-tance were analyzed in 395 patients with spinal cord injury in the hospital from Jun., 2012 to Dec., 2013. Results There were 132 cases with nosocomial infection. Most of the infections were found in urinary tract (71.1%) and lower respiratory tract (24.2%). The main pathogenic germs were Escherichia coli (45.6%), P. Aeruginosa (18.1%), K. pneumonia (11.4%) and P. mirabilis(8.7%), which were resistant to the sec-ond or third generation cephalosporins and quinolones moderately or severely, but sensitive toβ-lactamase inhibitor combinations and ami-noglycosides. Conclusion The main pathogenic bacteria in nosocomial infection of patients with spinal cord injury are G-bacilli. The bacte-ria are resistant moderately or severely to antibiotics, which should be selected rationally by bacterial culture and drug susceptibility test, and optimized rationally with PK/PD (pharmacokinetics and pharmacodynamics).关键词
脊髓损伤/医院感染/病原菌/抗菌治疗Key words
spinal cord injury/nosocomial infection/pathogens/antibiotic therapy分类
医药卫生引用本文复制引用
赵国伟,高钧..395例脊髓损伤患者医院感染的病原菌分布和耐药情况分析[J].中国康复理论与实践,2015,(4):460-463,4.
