中国康复理论与实践Issue(7)：770-772,3.DOI:10.3969/j.issn.1006-9771.2015.07.007
谷红注射液对脑缺血再灌注大鼠皮层血管内皮生长因子表达的影响
Effects of Guhong Injection on Expression of Vascular Endothelial Growth Factor in Cortex after Cerebral Isch-emia-reperfusion in Rats
摘要
Abstract
Objective To study the effects of Guhong injection on the expression of vascular endothelial growth factor (VEGF) in the cortex 14 days after cerebral ischemia-reperfusion. Methods 30 male Sprague-Dawley rats were divided into sham group (n=6), ischemia group (n=6), aceglutamide injection group (n=6), Honghua injection group (n=6) and Guhong injection group (n=6). The middle cerebral ar-teries of all the rats were occluded for 2 hours and reperfusion, except the sham group. Drugs were administered once a day 24 hours after re-perfusion. The expression of VEGF in cortex was detected with enzyme-linked immunosorbent assay (ELISA) 14 days after reperfusion. Re-sults The expression of VEGF decreased in the ischemia group compared with the sham group (P<0.001), and it increased both in the ace-glutamide and Guhong injection groups compared with the ischemia group (P<0.05). Conclusion Guhong injection can significantly in-crease the expression of VEGF in the cortex 14 days after ischemia-reperfusion, which may be one of the ways for neuro-protection.关键词
脑缺血再灌注/谷红注射液/血管内皮生长因子/大鼠Key words
cerebral ischemia-reperfusion/Guhong injection/vascular endothelial growth factor/rats分类
医药卫生引用本文复制引用
张蕊,梁珍,杨楠,纪超,刘雁勇,左萍萍..谷红注射液对脑缺血再灌注大鼠皮层血管内皮生长因子表达的影响[J].中国康复理论与实践,2015,(7):770-772,3.基金项目
1.国家自然科学基金项目(No.81100801)；2.菏泽步长制药有限公司项目。 （No.81100801）
