中国口腔种植学杂志Issue(4)：155-159,5.
rhBMP-2、PRF和自体骨分别复合珊瑚羟基磷灰石成骨效能的比较研究
The contrastive research on the osteogenesis effects of recombinant human bone morphogenetic protein-2, platelet-rich fibrin and autologous bone compositeding with coralline hydroxyapatite respectively
摘要
Abstract
Objective: By establishing bone defects animal model, the osteogenesis effects of four groups bone transplantation materials that they are compound of reco mbinant human bone morphogenetic protein-2 (rhBMP -2), coralline hydroxyapatite (CHA), compound of platelet -rich fibrin and coralline hydroxyapatite, compound of autologous bone and coralline hydroxyapatite and pure coralline hydroxyapatite were compared by repairing bone defects. Methods: Four same bone defects were prepared on each side of tibial metaphyseal of Beagles , rhBMP-2/CHA, PRF/CHA, autologous bone/CHA and pure CHA were respectively implanted into the bone defects. The Beagles were executed after three months, using gross specimen and dental CT to compare four groups bone growth in bone graft areas and bone mineral density; and decalcified paraffin section, HE staining were used to compare histological characteristics and osteogenesis quantity of new bones. Results: Gross specimen: the space between bone defects of four graft areas were completely closed. X-ray showed: the bone densities were more dense of autologous bone/CHA group and PRF/CHA group, the next for rhBMP-2/CHA group, and there is no significant dense bone density shadow in CHA group. HE staining showed that new bones and host bones were connected closely, new bone trabecular was irregular, varied, and the arrangement was disorderly; compared with CHA group, new bone trabeculars on bone graft areas of other three groups were more dense, thick, with better consecu- tiveness; osteogenesis quantity on bone graft areas of four groups were compared as following: autologous bone/CHA group>PRF/CHA group>rhBMP-2/CHA group>CHA group. Conclusion: osteogenesis effects of composite bone graft materials were much better than that of coralline hydroxyapatite alone;autologous bone/CHA was the best in the osteogenesis effects of three kinds of composite bone graft materials, and that of PRF/CHA was followed by, rhBMP-2/CHA was the last.关键词
重组人骨形成蛋白-2/血小板纤维蛋白/自体骨/珊瑚羟基磷灰石/骨缺损修复Key words
recombinant human bone morphogenetic protein-2/platelet-rich fibrin/autologous bone/coralline hydroxyapatite/bone defect repair引用本文复制引用
宋亚平,徐世同,杨淑娟,张彩美,黄丞蔚,刘虎..rhBMP-2、PRF和自体骨分别复合珊瑚羟基磷灰石成骨效能的比较研究[J].中国口腔种植学杂志,2014,(4):155-159,5.基金项目
广东省社会发展领域科技计划项目 （）
