中国临床药理学杂志Issue(6)：478-480,3.DOI:10.13699/j.cnki.1001-6821.2014.06.002
参附注射液对扩张型心肌病心力衰竭患者心功能及心室重构的影响
Effect of Shenfu injection on cardiac function and ventricular remodeling in patients with dilated cardiomyopathy associated with heart failure
摘要
Abstract
Objective To evaluate the clinical efficacy of Shenfu injec-tion on cardiac function of patients with dilated cardiomyopathy ( DCM ) associated with heart failure ( HF ) and its influence on brain natriuretic peptide ( BNP) , angiotensinⅡ( Ang-Ⅱ) , endothelin ( ET-Ⅰ) in plas-ma.Methods Eighty patients with DCM associated with HF were ran-domly divided into treatment group (n=40) and control group (n=40).Patients in the control group were only given conventional treatment of western medicine for two weeks , while patients in the treatment group were treated with Shenfu injection 50 mL on the basis of the conventional treat-ment for two weeks.The cardiac function,6 -minute walk test, and the change of BNP , Ang-Ⅱ, ET-Ⅰwere observed before and after treatment.Results The cardiac function and 6-minute walk test of the Shenfu treat-ment group improved remarkably compared with control group (P<0.05).The levels of BNP , Ang-Ⅱ, ET-Ⅰin both groups decreased significantly after treatment (P<0.05), and that in treatment group decreased more ob-viously compared with control group (P<0.05).Conclusion Shenfu in-jection can improve cardiac function of patients with DCM associated with HF, which also has therapeutic effects on the activation of neuroendocrine.关键词
参附注射液/心力衰竭/扩张型心肌病/脑钠肽/血管紧张素Ⅱ/内皮素Key words
Shenfu injection/heart failure/dilated cardiomyopathy/brain natriuretic peptide/angiotensin Ⅱ/endothelin分类
医药卫生引用本文复制引用
张芳,任开涵,陈玉林..参附注射液对扩张型心肌病心力衰竭患者心功能及心室重构的影响[J].中国临床药理学杂志,2014,(6):478-480,3.基金项目
浙江省科技计划基金资助项目 （）
