中国临床药理学杂志Issue(6)：493-496,4.DOI:10.13699/j.cnki.1001-6821.2014.06.007
胃复春和维 A酸对胃癌前病变患者基因 Rb和C-erbB-2表达的影响
Effect of the combination of Weifuchun and retinoic acid on the expression of Rb gene and C-erbB-2 gene in the patients with gastric precancerous lesions
李小雷 1王晓琦 1屈海鸥1
作者信息
- 1. 温岭市第一人民医院 外科，浙江 温岭317500
- 折叠
摘要
Abstract
Objective To explore the effect of the combination of Weifu-chun and retinoic acid on the expression of Rb Gene and C -erbB -2 Gene in the patients with gastric precancerous lesions.Methods One hundred and fifteen patients with gastric precancerous lesions were ran-domly divided into the observed group ( n =60 ) and the control group ( n=60 ).the group were all given omeprazole enteric -coated capsules and hydrotalcite tablets , and at the same time the observed group was ad-ministrated with Weifuchun ( 1.436 g every time , tid ) and retinoic acid (10 mg every time,tid).The expressions of Rb gene and C -erbB-2 gene were detected by immunohistochemistry and compared after 12 months treatment.Results The positive rate of Rb gene after treatment in the observed group(87.93%) was significantly higher than that before treatment in the observed group (68.97%) and after treatment in the con-trol group(71.93%)(P<0.05).The positive rate of C-erbB-2 gene after treatment in the observed group ( 12.07%) was significantly lower than that before treatment in the observed group ( 34.48%) and after treatment in the control group(29.82%)(P<0.05).Conclusion We-ifuchun and retinoic acid could medicate the expressions of gene Rb and C-erbB-2.关键词
胃复春/维A酸/胃癌前病变/抑癌基因Rb/癌基因CerbB-2Key words
Weifuchun/retinoic acid/gastric precancerous lesions/Rb/CerbB-2分类
医药卫生引用本文复制引用
李小雷,王晓琦,屈海鸥..胃复春和维 A酸对胃癌前病变患者基因 Rb和C-erbB-2表达的影响[J].中国临床药理学杂志,2014,(6):493-496,4.
