中国临床药理学杂志Issue(6)：543-545,3.DOI:10.13699/j.cnki.1001-6821.2014.06.023
补血Ⅰ号方对化疗药物环磷酰胺致血小板减少动物作用的实验研究
Experimental study of the effects of the Buxue I decoction about the rat thrombocy-topenia model caused by cyclophosphamide
摘要
Abstract
Objective To observe the cyclophosphamide effects of the Buxue I decoction on the thrombocytopenia caused by cyclophosphamide ( CTX).Methods Sixty thrombocytopenia models created by intraper-itoneal injection of CTX were randomly divided six groups ( n =10 each):the Buxue I low group (20.85 g· kg -1 ), the Buxue I moderate group (41.7 g· kg -1), the Buxue I high group (83.4 g· kg -1), the interleukin -11 control group , the normal control group and model group.Ten days is a treatment course.The effects about the different quantities on the thrombocytopenia , the megakaryocytes in bone narrow as well as the organ coefficient of spleen , thymus, and adrenal gland were observed.Results Compared with those of the model group , the amount of the platelets were increased in Buxue I decoction groups , a-mong which the high group had a significant difference ( P <0.005 ).The spleen index and the thymus index both were increased in the Buxue I decoction groups , and the thymus index had significant differences be-tween the high and the moderate group.The megakaryocytes were signifi-cantly enhanced by the high and low dose of Buxue I decoction ( P<0.05, P <0.01 ).Conclusion The Buxue I decoction can mitigate the inhibition of megakaryocytes caused by the CTX and it can contribute to the enhancing immunity.关键词
补血Ⅰ号方/血小板减少/环磷酰胺/动物模型Key words
buxue I decoction/thrombocytopenia/cyclophosphamide/animal model分类
医药卫生引用本文复制引用
周红,苏兰,郭宁栎..补血Ⅰ号方对化疗药物环磷酰胺致血小板减少动物作用的实验研究[J].中国临床药理学杂志,2014,(6):543-545,3.基金项目
四川省教育厅科研基金资助项目（IZZA045）；成都中医药大学校科研基金资助项目 （）
