摘要
Abstract
Objective To observe the effects and safety of dobesilate and benazepril combination therapy on early diabetic nephropathy ( DN).Methods One hundred and two cases of early DN patients were randomly divided into A, B, and C groups, and the same glyce-mic control method were adopted in three groups.Group A ( 34 pa-tients) were treated with dobesilate of 1000 mg 3 times a day orally, group B ( 33 patients) were treated with benazepril 10 mg a day oral-ly, and 35 patients in group C were treated with dobesilate of 1000 mg 3 times a day combined with enalapril 10 mg one day orally.Three groups were treated for l2 weeks.The changes of three groups before and after treatment in the mean arterial pressure ( MAP) , glycated he-moglobin ( HbA1 c ) , serum creatinine ( Scr ) , creatinine clearance rate ( Ccr ) , fibrinogen ( FIB ) and urinary albumin excretion rate ( UAER) were compared.Results Compared with pre-treatment, MAP, HbA1 c, Scr, Ccr levels of the three groups had no significant differences ( P>0.05 ) .FIB level of group A and C decreased signifi-cantly ( P <0.05 ) .UAER of three groups were decreased , and the group C decreased more significantly ( P<0.05 ).There was one case of skin allergies in group C.Conclusion Dobesilate and benazeprilcombination treatment for early diabetic nephropathy can effectively reduce UAER and FIB , reverse or slow the progress of early DN, with less adverse reactions.关键词
糖尿病肾病/羟苯磺酸钙/贝那普利/尿白蛋白排出率Key words
diabetic nephropathy/dobesilate/benazepril/urinary albumin excretion rate分类
医药卫生
