中国临床药理学杂志Issue(7)：571-574,4.DOI:10.13699/j.cnki.1001-6821.2014.07.004
左炔诺孕酮宫内缓释系统治疗子宫内膜异位症的临床疗效
Clinical effect of levonorgestrel-releasing intrauterine system in the treatment of endometriosis
摘要
Abstract
Objective To evaluate the safety of levonorgestrel -relea-sing intrauterine system ( LNG-IUS ) in the treatment of endometriosis ( EM) for 5 years.Methods A total of 49 patients with endometriosis were included.The LNG-IUS was inserted into uterine cavity.The ac-ne, facial pigmentation, mammary swelling, the body weight , the body hair and quality of life were scored and compared before and 6, 12, 36, and 60 months after the insertion of the LNG -IUS.Results Compared with prior treatment, the body weight and the scores of the body hair and facial pigmentation showed no marked change at each point of observation time ( P >0.05 ) , and the scores of quality of life and mammary swelling dropped significantly ( P <0.05 ).Six months after insertion, the score of acne had no marked change ( P>0.05 ) , but 12, 36, and 60 months later, it decreased significantly ( P<0.05 ).Conclusion LNG -IUS is safe for long -term treat-ment of endometriosis.关键词
左炔诺孕酮/药物缓释系统/子宫内膜异位症/安全性Key words
levonorgestrel/drug delivery system/endometriosis/safety分类
医药卫生引用本文复制引用
李晓红,陈志芳,丁岩..左炔诺孕酮宫内缓释系统治疗子宫内膜异位症的临床疗效[J].中国临床药理学杂志,2014,(7):571-574,4.基金项目
新疆维吾尔自治区自然科学基金资助项目 （）
