中国临床药理学杂志Issue(9)：762-764,3.DOI:10.13699/j.cnki.1001-6821.2014.09.003
利伐沙班预防老年髋关节置换术后下肢静脉血栓的临床疗效及安全性研究
Efficacy and safety of rivaroxaban in the prevention of deep vein thrombosis in patients with hip arthroplasty
摘要
Abstract
Objective To investigate the efficacy and safety of rivaroxa-ban in the prevention of deep vein thrombosis in patients with hip arthro-plasty.Methods Ninety-eight patients with hip arthroplasty were re-cruited in our hospital.The included 98 cases were randomized divided into rivaroxaban group ( n=46 ) with rivaroxaban 10 mg · d -1 orally with 5-week and low molecular heparin ( LMH) group with LMH 4100 U with 2-week.The risk of deep vein thrombosis between the two groups was recorded within the flowing 6 months.Results With a follow-up peri-od of 6 months, the incidence of deep vein thrombosis were 2.3%(1/44) and 14.6%(7/58) in the rivaroxaban group and LMH group re-spectively , which indicated the incidence was much lower in rivaroxaban group ( P<0.05 ).But the platelet count , coagulation function , drainage volume and subcutaneous ecchymosis were not different between the two groups ( P>0.05 ).Conclusion Rivaroxaban can significant decrease the risk of deep vein thrombosis in patients with hip arthroplasty without increasing the side effects.关键词
利伐沙班/髋关节置换术/下肢静脉血栓/低分子肝素Key words
rivaroxaban/hip arthroplasty/deep vein thrombosis/low molecular heparin分类
医药卫生引用本文复制引用
李坚,曾云记,谢金兔,庄汝杰..利伐沙班预防老年髋关节置换术后下肢静脉血栓的临床疗效及安全性研究[J].中国临床药理学杂志,2014,(9):762-764,3.基金项目
浙江省科技厅创新基金资助项目 （）
