中国临床药理学杂志Issue(9)：810-812,3.DOI:10.13699/j.cnki.1001-6821.2014.09.018
蒙特卡洛模拟优化磷霉素的给药方案
Optimization the dosing regimens of fosfomycin by Monte Carlo simulation
摘要
Abstract
Objective To compare the pharmadynamics of fosfomycin in different dosing regimens to obtain the optimal clinical dosing regimen by Monte carlo simulation.Methods Pharmacokinetic datas of fosfomycin in lung tissue of septic patients were determined by in vivo microdialysis , application software ( Crystal Ball 7.2.2 ) performed Monte Carlo simula-tion of 10 000 patients to calculate the probability of target attainment ( PTA) of different doseing regimens.And combined with maximum drug concentration/minimum inhibitory concentration ( cmax/MIC).Results Of all the dosing regimens , PTA(6 g/q6 h) is best, however, when MIC>20, the PTA<50%.The probability of cmax/MIC≥4:prolonged infu-sion therapy ( PIT) (6 g/q6 h)>PIT(4 g/q6 h)>optimized two-step infusion therapy (OTIT) (6 g/q6 h)>OTIT(4 g/q6 h).When MIC≤16 , the antimicrobial PTA is approximately 100%,while the bactericidal PTA reduces to 66.48%.Conclusion When MIC≤20 , the prolonged infusion therapy of 6 g/6 h is best; while MIC>20 , PTA<50%, with poor clinical results , the best choice was drug combination.关键词
磷霉素/延长输注/两步输注/蒙特卡洛/达标概率Key words
fosfomycin/prolonged infusion therapy/optimized two -step infusion therapy/Monte Carlo simulation/probability of target at-tainment分类
医药卫生引用本文复制引用
周静超,张睢扬,周丁华,童卫杭[,迟小华,王丹..蒙特卡洛模拟优化磷霉素的给药方案[J].中国临床药理学杂志,2014,(9):810-812,3.基金项目
国家自然基金青年科学基金资助项目（81301662）；中国博士后科学基金资助项目 （）
