中国临床药理学杂志Issue(9)：865-867,3.DOI:10.13699/j.cnki.1001-6821.2014.09.034
尿苷-5′-二磷酸葡萄糖醛酸转移酶对常见植物药组分的催化代谢及其相互作用
Catalytic metabolism and interaction of herbs and their components mediated by uridine 5′-diphosphate glucuronosyltransferases
摘要
Abstract
Uridine 5′-diphosphate glucuronosyltransferases ( UGT ) are the most important phase II drug metabolizing enzymes.They catalyze the glucuronidation of endogenous or exogenous chemicals , which then affect the pharmacokinetic characteristics of co -administrated drugs.Many herbs as well as their active ingredients are the substrates of UGT and their catalytic metabolism are mediated by UGT.This paper summarizes the catalytic metabolism of some herbs and their components mediated by UGT and their influence on UGT activity.关键词
尿苷-5′-二磷酸葡萄糖醛酸转移酶/葡萄糖醛酸化反应/催化代谢/相互作用Key words
uridine 5′- diphosphate glucuronosyltransferase/glucuronidation/catalytic metabolism/interaction分类
医药卫生引用本文复制引用
高瑞,陈昱,张文,夏春华,张红,黄世博,熊玉卿..尿苷-5′-二磷酸葡萄糖醛酸转移酶对常见植物药组分的催化代谢及其相互作用[J].中国临床药理学杂志,2014,(9):865-867,3.基金项目
国家自然科学基金资助项目（81060275，81160411）；国家十二五重大专项基金资助项目（2011ZX09302-007-03）；江西省自然科学基金资助项目（20132BAB205079）；江西省青年科学家培养对象基金资助项目 （）
