中国临床药理学杂志Issue(10)：915-918,4.DOI:10.13699/j.cnki.1001-6821.2014.10.014
安吡昔康在健康受试者多次给药的药代动力学研究
Pharmacokinetics of multiple doses ampiroxicam in Chinese healthy subjects
赵彩芸 1吕媛 1魏敏吉 1康子胜 1刘燕 1张曼1
作者信息
- 1. 北京大学 第一医院 临床药理研究所，北京 100034
- 折叠
摘要
Abstract
Objective To evaluate the pharmacokinetics of multiple doses of ampiroxicam tablets in Chinese healthy subjects .Methods A randomized, open study was conducted.Twelve subjects were orally administrated with 27 mg ampiroxicam tablets, once a day for 11 days. The blood samples were collected on the 8th , 9th , and 10th day before ad-ministration.On the 11 th day, the blood and urine samples were collected at different time points after administration , and the concentrations of am-piroxicam in serum and urine were determinated by HPLC method . Results One subject exited on the 7th day.The main pharmacokinetics parameters of 11 subjects after oral doses for 11 days were as follows:Cmax were(8.14 ±2.81) mg・ L-1; t1 /2β was (50.10 ±18.10 ) h; tmax was (5.60 ±4.10) h; AUC0 -∞ was (837.05 ±441.47 ) mg・ h・ L respectively.Urinary recovery rate was (0.55 ±0.51 )% from zero to 192 hours, respectively.Conclusion After multiple dosing, there was a very high trough concentration before dosing because of a very long half -life of ampiroxicam.Blood concentration and pharmacokinetic parameters are individually different, and little drug is excreted by kidney.关键词
安吡昔康/吡罗昔康/药代动力学/高效液相色谱法/多次给药Key words
ampiroxicam/piroxicam/pharmacokinetic/HPLC/multiple -dose分类
医药卫生引用本文复制引用
赵彩芸,吕媛,魏敏吉,康子胜,刘燕,张曼..安吡昔康在健康受试者多次给药的药代动力学研究[J].中国临床药理学杂志,2014,(10):915-918,4.
