中国临床药理学杂志Issue(10)：936-938,3.DOI:10.13699/j.cnki.1001-6821.2014.10.020
四逆散对大鼠睡眠时相影响的实验研究
Study on effects of Sini San on the sleeping phase in rats
摘要
Abstract
Objective To study on the effects of freeze -dry powder of Sini San on sleep in rats.Methods Rats were randomly divided into two groups (freeze -dry powder of Sini San and blank groups )of 15 each day to ensure the alternating light and dark 12 h.The postoperative recovery after two days, rats were continuously administered orally by freeze -dry powder of Sini San 4.95 g・ kg-1 for 7 days.Blank group was given dis-tilled water by intragastric way.The other disposal methods were the same with administration group.The efficacy of Sini San on sleeping phase of normal and insomnious rats are carried out by electroencephalo -gram (EEG).Results The total sleeping time (TST) of rats were sig-nificantly prolonged induced by pentobarbital sodium , especially slow -wave sleep 2 (SWS2) and rapid -eye -movement sleep (REMS) were prolonged after the rats were orally administrated of Sini San freeze -dry powder for seven days.The result indicated that Sini San can significant effect on improving sleep.Conclusion There was the function of Sini San in the treatment for insomnia.关键词
四逆散冻干粉/改善睡眠/睡眠时相/脑电图Key words
freeze - dry powder of Sini San/sleeping phase/electroencephalogram分类
医药卫生引用本文复制引用
李越峰,徐富菊,张泽国,严兴科..四逆散对大鼠睡眠时相影响的实验研究[J].中国临床药理学杂志,2014,(10):936-938,3.基金项目
国家自然科学基金资助项目（81460611）；教育部科学技术研究重点基金资助项目（212186）；2014年度甘肃省自然科学基金资助项目（1010RJZA212；145RJZA076）；甘肃省财政厅高校基本科研业务费专项基金资助项目（2013-2）；2010甘肃中医学院引进人才科研启动基金资助项目 （）
