中国临床药理学杂志Issue(10)：955-957,3.DOI:10.13699/j.cnki.1001-6821.2014.10.026
胃旁路手术对常用药物的药代动力学影响的研究进展
Progress in effects of Roux -en -Y gastric bypass surgery on pharmacokinetics of some kinds of common drugs
摘要
Abstract
Roux -en -Y gastric bypass (RYGB) is the golden standard surgeon to treat pathological obesity at present in the world .RYGB sur-geon could change the physical function and anatomic structure , it thus may make some uncertain effects on pharmacokinetics and pharmacody -namics of drugs.We retrieve references in recent years and make a review about how RYGB surgeon effect pharmacokinetics of vitamins , trace elements and antibacterials , et al.After RYGB surgeon, bioavail-ability of drugs may unchange, decrease or increase.Such variability is correlated with the absorption and metallization of drugs in vivo.关键词
胃旁路手术/药代动力学/安全性Key words
Roux -en -Y gastric bypass/pharmacokinetic/safety分类
医药卫生引用本文复制引用
菅凌燕,何晓静..胃旁路手术对常用药物的药代动力学影响的研究进展[J].中国临床药理学杂志,2014,(10):955-957,3.基金项目
辽宁省科学技术计划基金资助项目（2009225030）；国家十二五科技“重大新药创制”专项基金资助项目 （）
