中国临床药理学杂志Issue(11)：996-999,4.DOI:10.13699/j.cnki.1001-6821.2014.11.006
人附睾蛋白4在卵巢恶性肿瘤早期诊断中的作用
Application value of human epididymis protein 4 in early diagnosis of the ovary cancer
摘要
Abstract
Objective To determine the value of human epididymis pro-tein 4 ( HE4) in the diagnosis and prognosis of ovarian cancer.Methods We use the clinical case -control method, in which the level of HE4 and carbohydrate antigen -125 ( CA125 ) before operation in clinical case and normal women were detected.An immunohistochemistry meth-od was used to measure the expression of HE4 in different tissues.Statis-tical analysis was performed to determine the relationship between the level of HE4, the pathologic type of ovarian cancer, and the stage of the ovarian tumor.Results If the level of HE4 in the serum was 56.37 pmol· L-1 , the sensitivity of HE4 in diagnosing the malignant ovary tumor was 80%and the specificity was 96%.The level of HE4 and the pathological differentiation are negatively related and positively related to the clinical staging .HE4 in the malignant tumor group and borderline tumor group was higher than in other 3 groups, which contained bening ovary tumors, non-neoplastic lesions of ovary and other malignant gyne-cologic tumors.The HE4 level in the serum and HE4 in the tissue were relatively linked.Conclusion HE4 sensitivity and specificity in diagno-sing the ovary malignant tumor is higher than the sensitivity of CA125.The combined detection of HE4 and C125 is more effective.The level of HE4 in serum and HE4 in tissue was respectively closely related to the pathological type and clinical sequelae of the ovary malignant tumor.关键词
人附睾蛋白4/糖类抗原-125/卵巢肿瘤鉴别诊断/病理分型/电化学发光法/免疫组织化学Key words
human epididymis protein 4/carbohydrate antigen -125/differential diagnosis of the ovary tumor/pathologic typing/electrochemical luminescence method/immunohistochemistry分类
医药卫生引用本文复制引用
郑丽娥,曲军英,李桑,苏玉红..人附睾蛋白4在卵巢恶性肿瘤早期诊断中的作用[J].中国临床药理学杂志,2014,(11):996-999,4.基金项目
福建省卫生厅青年课题基金资助项目 （）
