中国临床药理学杂志Issue(1)：56-58,3.DOI:10.13699/j.cnki.1001-6821.2015.01.017
芍药苷改善睡眠作用机制研究
Study on sleep improving mechanism of Paeoniflorin
摘要
Abstract
Objective To study on sleep improving mechanism of Si Ni San Freeze -dry Powder.Methods Wistar rats were divided into four groups, each group was 10.Which were normal group, Si Ni San powder group, Radix Paeoniae Alba group.Paeoniflorin group.The freeze-dried powder 20 g, water dissolved into 0.5 kg・ L-1 solution, administered orally, the normal group were given equal volume of distilled water,1 times a day, continuous 7 d.Blood transitional component were analzed by HPLC method.Results By the analysis of the compound in cerebrospinal fluid, the endogenous substance in cerebrospinal fluid was increased obvi-ously.Increasing peak area of the endogenous substance in cerebrospinal fluid were about 12.5 times the blank′s in cerebrospinal fluid.Conclusion Paeoniflorin in Si Ni San Freeze-dry Powder improves sleep by promo-ting the secretion of 5-serotonin in cerebrospinal fluid.关键词
四逆散冻干粉/芍药苷/改善睡眠/机制Key words
SiNiSan Freeze -dry Powder/Paeoniflorin/improving sleeping/mechanism分类
医药卫生引用本文复制引用
李越峰,徐富菊,张泽国,李玉萍,严兴科..芍药苷改善睡眠作用机制研究[J].中国临床药理学杂志,2015,(1):56-58,3.基金项目
国家自然科学基金资助项目（81460611）；教育部科学技术研究重点基金资助项目（212186）；甘肃省自然科学基金资助项目（20101010RJZA212；2014145RJZA076）；甘肃省财政厅高校基本科研业务费专项基金资金项目（2013－2）；甘肃中医学院引进人才科研启动基金资助项目 （）
