中国临床药理学杂志Issue(2)：106-109,4.DOI:10.13699/j.cnki.1001-6821.2015.02.008
双氢青蒿素对非小细胞肺癌 A549细胞增殖及放疗增敏的影响
Dihydroartemisinin for non-small cell lung cancer A549 cell proliferation and the influence of radiotherapy sensitization
摘要
Abstract
Objective To investigate the inhibitory effect of dihydroarte-misinin ( DHA ) on non -small cell lung cancer A549 cells. Methods The IC10 of dihydroartemisinin was determined by the CCK-8 method, and low dose IC10was chosen as the experimental con-centration .CCK-8 was used to observe artemisinin in low doses of A 549 cell proliferation .The flow cytometry was adopted to detect the effect of DHA on the cycle and death of cells .The tablet clone formation experi-ment was used to detect the influence of DHA on radiation sensitivity . Results IC10 of dihydroartemisinin was 23.47 μmol · L-1 , and di-hydroartemisinin can inhibit proliferation of A 549 cells, slow down the cell cycle , control the cycle in S stage , and increase the radiation sensi-tivity.Conclusion Dihydroartemisinin can inhibit cell proliferation , increase the radiation sensitivity .关键词
双氢青蒿素/非小细胞肺癌/增殖/细胞周期/放疗敏感性Key words
dihydroartemisinin/non-small cell lung cancer/prolifera-tion/cell cycle/radiation sensitivity分类
医药卫生引用本文复制引用
廖奎,李海玉,彭志平,李娟..双氢青蒿素对非小细胞肺癌 A549细胞增殖及放疗增敏的影响[J].中国临床药理学杂志,2015,(2):106-109,4.基金项目
重庆市自然科学基金资助项目（2010BB5358）；重庆市渝中区科委基金资助项目 （）
