中国临床药理学杂志Issue(2)：116-118,134,4.DOI:10.13699/j.cnki.1001-6821.2015.02.011
达格列净对2型糖尿病患者血糖及心血管危险因素影响的 Meta分析
Meta-analysis on effects of dapagliflozin on hyperglycaemia and cardiovascular risk factors for patients with type 2 diabetes
石佳 1方振威 1林阳1
作者信息
- 1. 首都医科大学 附属北京安贞医院 药事部，北京 100029
- 折叠
摘要
Abstract
Objective To evaluate the effect of dapagliflozin on hyper-glycaemia and cardiovascular risk factors.Methods Cochrane library , PubMed, EmBase, CNKI, Wanfang database and trial register websites were searched to identify randomized controlled trials ( RCT).The quali-ty of included studies was assessed and Meta -analysis was performed by RevMan5.2.Results Fourteen RCTs involving 7 976 patients were in-cluded.Compared with placebo , dapagliflozin could significantly reduce levels of HbA1c and fasting plasma glucose , significant improvements of body weight , blood pressure , and blood cholesterol were also achieved while the incidences of hypoglycaemia were similar .Conclusion Dapa-gliflozin could significantly improve control of hyperglycaemia and cardio-vascular risk factors in patients with type 2 diabetes.关键词
达格列净/2型糖尿病/Meta分析/心血管Key words
dapagliflozin/type 2 diabete/Meta -analysis/heart and blood vessel分类
医药卫生引用本文复制引用
石佳,方振威,林阳..达格列净对2型糖尿病患者血糖及心血管危险因素影响的 Meta分析[J].中国临床药理学杂志,2015,(2):116-118,134,4.
