中国临床药理学杂志Issue(2)：127-129,3.DOI:10.13699/j.cnki.1001-6821.2015.02.014
老年患者万古霉素血药浓度监测与疗效评估
Evaluation on the therapeutic drug monitoring data of vancomycin and its efficacy and renel toxicity in elder patients
曲丹 1陈愉 1谷秀 1徐小嫚1
作者信息
- 1. 中国医科大学 附属盛京医院 呼吸科，沈阳110004
- 折叠
摘要
Abstract
Objective To evaluate the drug plasma concentration , clini-cal efficacy and renal toxicity of vancomycin .Methods The clinical da-ta ( basic disease , bacteriological results , the serum concentrations of vancomycin , clinical efficacy , renal toxicity and initial dose selection ) of 39 elder patients were retrospectively analyzed.Results The effective rate of vancomycin was 82.05%.Vancomycin trough concentration be-tween 10-20 mg · L-1 accounted for 48.12%.Among the 19 patients whose vancomycin trough concentrations were less than 10 mg · L-1 , 6 cases adjusted the dose , 2 cases ( 5.13%) had renal toxicity , but the creatinine returned to basal levels after vancomycin was reduced or stopped.Renal toxicity didn′t appear in 3 cases (7.69%) who had renal insufficiency before using vancomycin.When vancomycin was combined with etimicin and diuretics , renal toxicity didn′t appear.Conclusion The dose of vancomycin should be adjusted in elder pa-tients.We should monitor serum concentration of vancomycin to adjust its legitimately use.关键词
老年/万古霉素/血药浓度监测/肾毒性Key words
elderly/vancomycin/serum drug monitoring/renal toxicity分类
医药卫生引用本文复制引用
曲丹,陈愉,谷秀,徐小嫚..老年患者万古霉素血药浓度监测与疗效评估[J].中国临床药理学杂志,2015,(2):127-129,3.
