中国临床药理学杂志Issue(2)：146-149,4.DOI:10.13699/j.cnki.1001-6821.2015.02.021
肠促胰岛素相关药物的药代动力学／药效学模型研究进展
Review on pharmacokinetic/pharmacodynamic models of the related agents of incretin
臧彦楠 1方翼2
作者信息
- 1. 北京大学人民医院药剂科，北京 100044
- 2. 北京大学 药学院 药事管理与临床药学系，北京 100191
- 折叠
摘要
Abstract
Incretin is a hormone released from the L -cells in the gut wall under the stimulation of food and can promote the insulin secretion.The related agents used in the clinic mainly include two types , the gluca-gon-like peptide-1 ( GLP-1 ) receptor agonists and dipeptidyl pepti-dase -4 ( DPP -4 ) inhibitors.Pharmacokinetic/pharmacodynamic ( PK/PD) models of incretin related agents can be useful tools in optimal drug therapy in patients and support the design of future clinical trials.Meanwhile , a mechanism-based model can be more powerful at predic-ting physiological characteritics and the probability of successful outcome of anti -diabetic treatment for different dosage regimens of the drugs , which will be beneficial for new drugs development and dosage regimens regulation.The present review is focused on the mechanism -based PK/PD models of representative drugs which belong to GLP -1 receptor agonists and DPP-4 inhibitors.关键词
肠促胰岛素/胰高血糖素样肽-1受体激动剂类似物/二肽基肽酶-4抑制剂/药代动力学/药效学结合模型Key words
incretin/glucagon -like peptide -1 receptor agonists/dipeptidyl peptidase -4 inhibitors/pharmacokinetic/pharmacodynamic models分类
医药卫生引用本文复制引用
臧彦楠,方翼..肠促胰岛素相关药物的药代动力学／药效学模型研究进展[J].中国临床药理学杂志,2015,(2):146-149,4.
