中国临床药理学杂志Issue(3)：172-174,3.DOI:10.13699/j.cnki.1001-6821.2015.03.004
缬沙坦联合阿托伐他汀治疗早期糖尿病肾病的临床研究
Clinical efficacy of valsartan combined with atorvastatin on patients with diabetic nephropathy
摘要
Abstract
Objective To evaluate the effect and safety of valsartan combined with atorvastatin in the treatment of early stage diabetic nephropathy ( DN).Methods Sixty-three patients with early stage DN were recruited in this study and divided into two groups.The patients in experiment group ( n =30 ) were given valsartan 80 mg· d -1 combined with atorvastatin 20 mg · d -1 , and the control group ( n =33 ) were only given valsartan treatment.The treatment lasted for 4 months.After treatment, the data of serum level of serum creatinine ( Scr) , urinary albumin excretion rate ( UAER) , glomeru-lar filtration rate ( GFR ) and β2 -microglobulin (β2 -MG ) were compared between the two groups.Results After 4 -month treat-ment, the serum Scr, UAER and β2 -MG were decreased in both groups ( P<0.05 ) , but the changes in experiment group was much more significant than that in control group ( P<0.05 ).The adverse reactions such as cough, headache and dizziness were not statistically different between the two groups ( P<0.05 ).Conclusion Valsar-tan combined with atorvastatin treatment can improve the clinical efficacy in the treatment of diabetic nephropathy, without increasing adverse reactions.关键词
糖尿病肾病/缬沙坦/阿托伐他汀/临床疗效Key words
diabetic nephropathy/valsartan/atorvastatin/clinical efficacy分类
医药卫生引用本文复制引用
廖益飞,傅槟槟,桂志红,兰乐建,许伟海,项美娟..缬沙坦联合阿托伐他汀治疗早期糖尿病肾病的临床研究[J].中国临床药理学杂志,2015,(3):172-174,3.基金项目
省卫生厅科技基金资助项目 （）
