中国临床药理学杂志Issue(4)：250-252,258,4.DOI:10.13699/j.cnki.1001-6821.2015.04.003
阿奇霉素联合辛伐他汀治疗慢性阻塞性肺疾病合并肺动脉高压的临床疗效
Clinical efficacy of azithromycin combined simvastatin in the treatment of chronic obstructive pulmonary disease combined with pulmonary hypertension
摘要
Abstract
Objective To evaluate the clinical efficacy of azithromycin combined simvastatin in patients with chronic obstructive pulmonary disease ( COPD ) combined with pulmonary hypertension.Methods Sixty patients with COPD combined with pulmonary hypertension were randomly divided into treatment group ( n =30 ) and control group (n=30).Patients in control group was treated with simvastatin 20 mg, based on which patients in treatment group was given azithromycin enteric-coated tablets 0.25 g.The treatment lasted for six months.Data of par-tial pressure of blood oxygen, oxygen saturation, 6 min walking distance, forced vital capacity ( FVC ) , forced expiratory volume in one second ( FEV1 ) , pulmonary systolic pressure as well as diastolic pressure and C-reactive protein ( CRP ) levels were compared between two groups before and after treatment.Results After treatment, data of partial pressure of blood oxygen, oxygen saturation, 6 min walking distance, FVC and FEV1 were significantly higher in treatment group than those before treatment ( P <0.05 ); data of f pulmonary systolic pressure, diastolic pulmonary, and CRP levels were significantly lower than those before treatment ( P <0.05 ); data of triglyceride ( TG ) , serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) was significantly lower in the treatment group than those in the control group, while high -density lipoprotein cholesterol ( HDL -C ) was significantly higher in the treatment group ( P<0.05).There was no statistically significant difference found between two groups in terms of liver function ( P>0.05 ) .Conclusion Azithromycin combined with simvastatin in the treatment of COPD with pulmonary hypertension is safe with a significant efficacy.关键词
阿奇霉素/辛伐他汀/慢性阻塞性肺疾病/肺动脉高压Key words
azithromycin/simvastatin/chronic obstructive pulmonary disease/pulmonary hypertension分类
医药卫生引用本文复制引用
马肖龙..阿奇霉素联合辛伐他汀治疗慢性阻塞性肺疾病合并肺动脉高压的临床疗效[J].中国临床药理学杂志,2015,(4):250-252,258,4.基金项目
浙江省嘉兴市医学重点学科呼吸病学基金资助项目 （）
