中国临床药理学杂志Issue(4)：264-266,3.DOI:10.13699/j.cnki.1001-6821.2015.04.008
阿托品对靶控输注诱导气管插管时脑电双频指数的影响
Influence of atropine on the bispectral index response to endotracheal intubation induced by target controlled infusion
摘要
Abstract
Objective To evaluate the influence of atropine on the bis-pectral index( BIS) response to endotracheal intubation induced by target controlled infusion. Methods Seventy patients who were scheduled laparoscopic cholecystectomy were randomly divided into atropine group and control group, 35 patients in each group.First, patients in two groups were induced by target controlled infusion, with propofol and remifentanil pumped.After four minutes, patients received either atro-pine ( 10 μg・ kg-1 ) or an equal volume of 0.9% NaCl injection.Tra-cheal intubation was performed 10 minutes after anesthetic induction. The data of BIS, mean arterial pressure( MAP) and heart rate( HR) were recorded during the 15 -minute anesthesia induction. Results BIS values of the two groups 1 minute after intubation were significantly in-creased compared with those before intubation ( P <0.05 ) .Compared with control group, BIS values in atropine group were significantly higher three and five minutes after intubation [(52.83 ±4.00) vs (48.8 ±4.00), (48.9 ±4.00) vs (46.53 ±4.20)] (P<0.05).There were statistical differences between two groups in the data of MAP and HR 2 minutes before intubation, immediately before intubation, as well as three and five minutes after intubation, respectively.Conclusion Atropine can increase BIS value response to endotracheal intubation induced by target controlled infusion.关键词
阿托品/脑电双频指数/气管插管/靶控输注/丙泊酚Key words
atropine/bispctral index/endotracheal intubation/target-controlled infusion/propofol分类
医药卫生引用本文复制引用
程李健,徐慧,殷萍,兰允平..阿托品对靶控输注诱导气管插管时脑电双频指数的影响[J].中国临床药理学杂志,2015,(4):264-266,3.基金项目
浙江省衢州市科技局基金资助项目 （）
