中国临床药理学杂志Issue(5)：326-329,4.DOI:10.13699/j.cnki.1001-6821.2015.05.002
右美托咪啶对小儿心导管术全麻及苏醒质量的影响
Effect of dexmedetomidine on general anesthesia maintenance and recovery on children receiving cardiac catheterization
摘要
Abstract
Objective To investigate the effect of dexmedetomidine on general anesthesia maintenance and recovery on children receiving cardi-ac catheterization.Methods Eighty-four children undergoing cardiac catheterization ( 1 -11 years old ) were randomly divided into two groups:41 cases in dexmedetomidine combined with sevoflurane group (DS group) cases and 43 cases in sevoflurane group (S group).All of the children were injected with katemine 1 mg· kg-1.Then dexmedeto-midine was injected with an initial loading dose ( 1 μg · kg -1 ) for 10 minutes followed by a continuous infusion ( 2 μg · kg-1 · h-1 ) in DS group.Normal saline was injected in S group.The depth of anesthesia in all patients were monitored by bispectral index ( BIS) , which were main-tained between 55 and 65 through adjusting sevoflurane inhalation.During operation, the data of heart rate (HR), mean arterial pressure ( MAP) , respiration rate ( RR ) , BIS, pressure of end -tidal carbon dioxide ( Pet CO2 ) and concentration of end-tidal sevoflurane ( Cet Sev ) of children at the time to enter the operating room ( T0 ) , the time point of laryngeal mask ( LMA ) insertion ( T1 ) , 20 min after LMA ( T2 ) , the time point of LMA removed ( T3 ) were recorded, as well as the time of operation and recovery, complication including supplemental sedatives, and the rate of respiratory depression, nausea and vomit.Results The data of HR in DS group were significantly lower at T1, T2and T3 compared with S group (P<0.01).The exhaled sevoflurane concentra-tion of DS group was significantly lower at T2 and T3 than S group ( P<0.01 ).The recovery time of DS group was significantly longer than those of S group ( P<0.01 ).The cases requiring supplemental sedatives in DS group were less than that in S group(12 vs 37, P<0.01).Conclusion Dexmedetomidine is advantageous on general anesthesia maintenance and recovery in children receiving cardiac catheterization.关键词
右美托咪啶/儿童/七氟烷/心导管术Key words
dexmedetomidine/children/sevoflurane/cardiac catheterization分类
医药卫生引用本文复制引用
秦培顺,刘华程,黄静,叶雪飞,李兴旺..右美托咪啶对小儿心导管术全麻及苏醒质量的影响[J].中国临床药理学杂志,2015,(5):326-329,4.基金项目
浙江省自然基金资助项目（ Y2110380）；温州市科技局项目 （）
