中国临床药理学杂志Issue(5)：330-332,3.DOI:10.13699/j.cnki.1001-6821.2015.05.003
地特胰岛素联合瑞格列奈治疗2型糖尿病的临床对照研究
Clinical study of insulin detemir combined with repaglinide in the treatment of type 2 diabetes
摘要
Abstract
Objective To evaluate the efficacy and safety of insulin det-emir combined with repaglinide on the treatment of type 2 diabetes.Methods Eighty five cases with type 2 diabetes and not responsive to more than two abtidiabetic drugs were recruited in this study, and then were randomized divided into the experiment group ( n=41 ) and control group ( n=44 ).Patients in the experiment group were given treatment of insulin detemir 0.1 U· kg -1 through hypodermic injection at 22∶00 com-bined with repaglinide 0.5-1.0 mg 15 minutes before three meals, and those in the control group were treated with insulin aspart 30, 0.5-1.0 U· kg-1 through hypodermic injection 10 minutes before breakfast and dinner.The treatment lasted for three months.The data of fasting plasma-glucose ( FPG ) , 2 -hour postprandial plasma glucose ( 2 h PG ) , hemoglobin A1C ( HbA1C ) and so on were recorded and compared between the two groups.Results The serum level of FPG, 2 h PG and HbA1C were significantly decreased in the two groups after treatment ( P<0.05) , and glucose level in the experiment group was stabler than the control group.Levels of fasting blood -glucose C peptide and 2 -hour postprandial blood-glucose C peptide were statistically decreased in the both groups(P<0.05), with a more significant decrease found in experiment group(P<0.05).The risk to devel-op glucopenia was much higher in the control group than that in the experiment group( P<0.05).Conclusion Insu-lin detemir combined with repaglinide can significantly decrease the serum level of glucose in patients with type 2 diabe-tes with low risk to develop glucopenia.关键词
2型糖尿病/地特胰岛素/瑞格列奈/门冬胰岛素30/临床试验对照研究Key words
type 2 diabetes/insulin detemir/repaglinide/insulin aspart 30/clinical study分类
医药卫生引用本文复制引用
刘开平,杨绪兰,沈国清,周晓芳,蔡海刚,朱荔,丘红梅,李薇,姚纪瑜,陈纯娴..地特胰岛素联合瑞格列奈治疗2型糖尿病的临床对照研究[J].中国临床药理学杂志,2015,(5):330-332,3.基金项目
卫生厅青年基金项目 （）
