中国临床药理学杂志Issue(7)：495-497,3.DOI:10.13699/j.cnki.1001-6821.2015.07.003
草酸艾司西酞普兰联合奥氮平治疗老年抑郁症的临床疗效及安全性研究
Escitalopram oxalate combined with olanzapine in the treatment of depressive disorder in elderly patients
摘要
Abstract
Objective To assess the clinical efficacy and adverse reac-tions of olanzapine combined with escitalopram oxalate on depressive disorder in elderly patients.Methods Sixty two elderly patients with depressive disorder were recruited from February 2012 to April 2014 in our hospital and were randomized divided into the control group ( n=33 ) and experiment group ( n=29 ).Patients in the control group were given escitalopram oxalate 10 mg · d-1 orally for 8 weeks and patients in the experiment group were given escitalopram oxalate 10 mg · d-1 combined olanzapine 2.5 mg· d-1 ( initially) ,ranging from 5 to 10 mg· d-1 within the first week.The data of hamilton depression scale ( HAMD) and treat-ment emergent symptom scale ( TESS ) score were recorded between the two groups to evaluate the clinical efficacy and adverse reactions before treatment and 1, 2, 4, 6 and 8 weeks after treatment.Results From the end of the second week to the eighth week , the HAMD scale were significantly decreased in both groups ( P <0.05 ).At the end of the fourth week to the eighth week , the HAMD score in the experiment group were significantly lower than those in control group ( P <0.05 ).After 8 weeks, more than 10%patients in the experiment group showed weight gain , higher than those in the control group (P<0.05).The other adverse reactions such as dizziness , dry mouth, constipation and nausea showed no statistical differences( P>0.05 ).Conclusion Olanzapine combined with escitalopram oxalate in the treatment of depressive disorder in elderly patients can rapidly improve the symptom and have better clinical efficacy , but the weight gain was a common adverse reaction.关键词
奥氮平/草酸艾司西酞普兰/老年/抑郁症/临床疗效Key words
olanzapine/escitalopram oxalate/elderly/depressive disorder/clinical efficacy分类
医药卫生引用本文复制引用
郑学宝,王洪飞,吴新君,郑维芳..草酸艾司西酞普兰联合奥氮平治疗老年抑郁症的临床疗效及安全性研究[J].中国临床药理学杂志,2015,(7):495-497,3.基金项目
台州市科技计划基金资助项目 （）
