中国临床药理学杂志Issue(7)：501-504,4.DOI:10.13699/j.cnki.1001-6821.2015.07.005
通心络对自发性高血压大鼠肾损害的保护作用及机制
Protection effect of Tong Xin Luo on the renal damage in spontaneously hypertensive rats and its potential mechanism
摘要
Abstract
Objective To explore the effect of Tong Xin Luo ( TXL) on the renal damage by hypertension in spontaneously hypertensive rats ( SHR).Methods Ten week -old male SHR ( n=48 ) were randomly divided into 5 groups:control group , the amlodipine group , the amlodi-pine and different dose TXL groups.The same old male Wistor -Kyoto ( WK) rats was as control group .At the time of 20 weeks later after treatment, blood pressure, urine microalbumin, urine β2 -microglobulin were detected , the gene expression of angiotensin -converting enzyme 2 (ACE2) and angiotensin II type 1 receptor (AT1R) in rats kidney were determined.Results Compared with Wistar -Kyoto ( WKY ) control group, 10 week -old SHR showed higher levels of urine β2 MG and ACE2 , but less AT1 R.After treatment for 20 weeks, compared with the amlodipine group , amlodipine with TXL reduced urinary β2 -microglo-bulin and urine microalbumin , decreased AT 1 R expression and increased ACE2 expression.Conclusion Taking high-dose TXL with antihyper-tensive therapy could prevent renal damage progression , and its effect may be through lowering albuminuria , increasing renal ACE 2 expression , and decreasing AT 1 R expression.关键词
通心络/自发性高血压大鼠/血管紧张素转化酶2/氨氯地平Key words
Tong Xin Luo/spontaneously hypertensive rats/renal damage/angiotensin-converting enzyme 2/amlodipine分类
医药卫生引用本文复制引用
陈申杰,叶武,朱敏,陈洁,冯培芳..通心络对自发性高血压大鼠肾损害的保护作用及机制[J].中国临床药理学杂志,2015,(7):501-504,4.基金项目
浙江省自然科学基金资助项目 （）
