中国临床药理学杂志Issue(7)：526-529,4.DOI:10.13699/j.cnki.1001-6821.2015.07.012
红芪多糖减缓糖尿病肾病小鼠病程进展的作用机制研究
Study on the effective mechanisms of Hedysarum polybotrys polysacchcaide on delay the development of diabetic nephropathy in mice with diabetic nephropathy
祁雪艳 1金智生 1关雁 1魏玉娇 1朱真灵1
作者信息
- 1. 甘肃中医学院中医临床学院，兰州 730000
- 折叠
摘要
Abstract
Objective To investigate the protection effect of Hedysarum polybotrys polysacchcaide ( HPS) on early diabetic nephropathy ( DN) in db/db mice.Methods Fifty db/db male mice ( five weeks old ) were randomly divided into five groups:HPS ( low-dose , mid-dose , hing-dose) groups, telmisartan group, model group.Ten db/m mice ( five weeks old ) were employed as normal group.At the beginning of 6 weeks, were respectively given 200,100, and 50 mg · kg -1 HPS; 5 mg· kg-1 telmisartan.The mice in normol group and model group were given 0.9%NaCl by gavege.The 24 hours urine protein were measured after administration 8 weeks and kill the mice with remove blood and serum was isolated from the eye .And the related indexes were evaluated.Results After interventing 8 weeks,compared with model group , serum creatinine ( Scr) 24 hours urine proteinall in HPS and telmisartan groups decreased ( P<0.05 ).The levels of blood glucose , blood urea nitrogen ( BUN ) , the expression of p 38 mitogen -activated protein kinase ( p38 MAPK ) and matrix metalloproteinases ( MMPs ) mRNA all decreased , but only the high , middle doses groups of HPS were statisti-cally difference ( P <0.05 ) .Conclusion Which indicates that HPS could delay the development of DN by inhibiting the P 38MAPK,MMPs protein and mRNA expression in the glomerular mesangial cell membrane.关键词
红芪多糖/糖尿病肾病/p38 丝裂原活化蛋白激酶/基质金属蛋白酶/db/db小鼠Key words
Hedysarum polybotrys polysacchcaide/diabetic nephropathy/p38 mitogen -activated protein kinase/matrix metalloproteinases/db/db mice分类
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祁雪艳,金智生,关雁,魏玉娇,朱真灵..红芪多糖减缓糖尿病肾病小鼠病程进展的作用机制研究[J].中国临床药理学杂志,2015,(7):526-529,4.
