中国临床药理学杂志Issue(7)：560-562,572,4.DOI:10.13699/j.cnki.1001-6821.2015.07.022
复方金沙利胆颗粒药效学及急性毒性研究
Experimental study on pharmacodynamics and acute toxicity of compound Jinshalidan Granules
摘要
Abstract
Objective To investigate the cholagogic and anti -infla-mmatory effects and acute toxicity of Jinshalidan Granules.Methods The cholagogic effect of Jinshalidan Granules was observed and deter-mined by common bile duct drainage in mouse .The acute inflammatory models was established by xylene -induced ear edema to research the inflammatory effects of Jinshalidan Granules.The acute toxicity and the maximum tolerated dose in mice were also studied.Results Compared with the normal control group , the bile secretion for the mouse and the degree of swelling of mice ear induced by xylene were significantly improvemed in all the 3 different dosages of Jinshalidan Granules.After 14 days, continuous observation ,no mouse was found dead and no signifi-cant toxicity occurred by naked eyes.The maximum tolerated dose of Compound Jinshalidan Granules is 244.8 g · kg -1 ( crude drug ).Conclusion Compound Jinshalidan Granules have obviously effects on the increased the bile secretion and anti -inflammatory ,it is has very low acute toxicity in mice and preliminary proven to be safe .关键词
复方金沙利胆颗粒/药效学/利胆/抗炎/急性毒性Key words
Compound Jinshalidan Granule/pharmacodynamics/cholagogic/anti-inflammatory/acute toxicity分类
医药卫生引用本文复制引用
易爱玲,邹福生,魏盈盈,陈炜,杜光..复方金沙利胆颗粒药效学及急性毒性研究[J].中国临床药理学杂志,2015,(7):560-562,572,4.基金项目
武汉市临床医学科研基金资助项目 （）
