中国临床药理学杂志Issue(8)：590-591,594,3.DOI:10.13699/j.cnki.1001-6821.2015.08.002
盐酸米诺环素软膏联合替硝唑治疗慢性牙周炎的临床疗效及安全性研究
Clinical effect and safety of minocycline combined with tinidazole on chronic periodontitis
摘要
Abstract
Objective To evaluate the clinical effect and safety of mino-cycline combined with tinidazole on chronic periodontitis .Methods A total of 102 patients with chronic periodontitis were recruited in this pro-spective study and were divided into experiment group ( n=49 ) and con-trol group ( n =53 ) .Patients in control group were given minocycline once a week for 4 weeks and patients in experiment group were given mi-nocycline once a week plus tinidazole 250 mg per day for 4 weeks.The data of clinical efficacy and adverse reactions were evaluated after the treatment.Results The excellence rate were 93.8%and 63.3%in ex-periment and control group respectively , which indicated a higher rate in experiment group but with out statistical difference (P>0.05).And the adverse reactions such as nausea , itchy skin and dizziness were not statis-tically different between the two groups ( P<0.05 ).Conclusion Mino-cycline combined with tinidazole in the treatment of chronic periodontitis is effective , and not increasing the adverse reactions .关键词
慢性牙周炎/盐酸米诺环素/替硝唑/临床疗效/安全性Key words
chronic periodontitis/minocycline/tinidazole/clinical effi-cacy/safety分类
医药卫生引用本文复制引用
张大风,黄盛斌,张友婷,邓辉..盐酸米诺环素软膏联合替硝唑治疗慢性牙周炎的临床疗效及安全性研究[J].中国临床药理学杂志,2015,(8):590-591,594,3.基金项目
浙江省自然科学基金资助项目 （）
