中国临床药理学杂志Issue(8)：595-598,4.DOI:10.13699/j.cnki.1001-6821.2015.08.004
氯吡格雷联合阿司匹林治疗急性心肌梗死的临床研究
Clinical study of clopidogrel combined with aspirin in the treatment of acute myocardial infarction
摘要
Abstract
Objective To evaluate the significance of platelet function monitoring in anti -platelet treatment of acute myocardial infarction . Methods The platelet maximum aggregation rates ( MAR ) induced by arachidonic acid , adenosine diphosphate and collagen were detected in 60 cases of acute myocardial infarction .The platelet aggregation function was compared before and after anti -platelet therapy for 24 h and 1 week.The plasma concentration of clopidogrel acid was detected and the correlation between concentration of clopidogrel acid and platelet aggrega-tion was analyzed.Results The MAR induced by arachidonic acid , adenosine diphosphate and collagen were significantly decreased after an-tiplatelet treatment for 24 h( P<0.01 );but after 1 week, no further re-duce in platelet aggregation rate was found , which showed some tole-rance.After 24 h, patients with MAR decreased by more than 30% ac-counted for 36.5%, 40.4% and 21.2%, respectively induced by arachidonic acid , adenosine diphosphate and collagen; patients with MAR decreased by 10% -29% accounted for 30.8%, 25%, and 34.6%,respectively,andthosewithMARdecreasedlessthan10%accountedfor34.6%,36.5%and44.2%,re-spectively.During half year follow -up, 34% of patients showed reoccurrence of cardiovascular events , and 55% of them were found aggregation rate less than 30%.Conclusion The aggregation rates under induction of arachidonic acid, adenosine diphosphate and collagen are all less than 30%when adopting the same anti -palate regime, but the incidence of cardiovascular events increased significantly and the platelet aggregation function and blood concentration of clopidogrel acid has no correlation .关键词
急性心肌梗死/血小板最大聚集率/花生四烯酸/腺苷二磷酸/胶原Key words
acute myocardial infarction/platelet maximum aggregation rate/arachidonic acid/adenosine diphosphate/collagen分类
医药卫生引用本文复制引用
赵亚男,王晨,蔚有权,李相鸿,曹蘅..氯吡格雷联合阿司匹林治疗急性心肌梗死的临床研究[J].中国临床药理学杂志,2015,(8):595-598,4.基金项目
安徽省教育厅重点基金资助项目 （）
